Globalization and interdependence are the two central components that have changed the nature of power as well as our understanding of security in four major ways. First, the dynamics of international security have changed the power distribution across the board. Nowadays not only the United States but also the Russian Federation, the People’s Republic of China, and the European Union are considered “big powers.” Second, the increase in the volume of global trade, international communication and travel as well as the emergence of the Industry 4.0 have created an integrated global economy and made it necessary to take into account some new actors, means, and perspectives for sustaining and promoting international security. Third, globalization and interdependence may lead to a butterfly effect in that local problems may turn into major international threats and challenges that would affect regional and global security. Finally, because there is no one institution that would act as a global government and create a just global system, globalization, in fact, functions in a way to increase international anarchy and complexity. This, in turn, heightens security concerns and calls for a creative problem-solving approach.