The Mesopotamian Civilization was the first complex civilization. There followed on the same ground the following people who dominated this civilization’s development, activities, and fall and built subsequent ones. The Sumerians (5000-2300 BCE) were the first humans known to form a civilization. The Akkadians (2334 – 2193 BCE) came next. Then the Babylonians (2004-1595 BCE and 625-539 BCE) established the city of Babylon, which became the most influential city in Mesopotamia and they dominated the territory. The Assyrians (870-612 BCE) came from the northern part of Mesopotamia. They were a warrior society. They also reigned much of the Middle East at different periods over the history of Mesopotamia. The Persians (539-323 BCE) laid an end to the rule of the Assyrians and the Babylonians. They conquered much of the Middle East including Mesopotamia. The correct answer is D.